Medical education

The Fatigue Factor: Do Blood Thinners Make You Tired?

Journal Circulation: Cardiovascular Quality and Outcomes 2023 suggest that some individuals might experience fatigue while taking blood thinners. It’s estimated that about one in five patients might have this experience. Fortunately, this side effect is not encountered by most individuals. You may not have this in your general awareness that your veins and arteries are the carriers of your blood flow.

Do blood thinners make you tired? If you have an irregular heart rhythm, your doctor might consider prescribing blood thinners. This approach is common for individuals with a higher risk of heart attack, stroke, or pulmonary embolism. It’s a proactive measure to support your heart health and overall well-being.

Do Blood Thinners Make You Tired?

Medications used to treat and prevent heart attacks often include anticoagulants or blood thinners. These medications work by interacting with the body’s natural blood flow. Still, it’s important to remember that their purpose is to support heart health and reduce the risk of serious complications. We recall receiving this question that left room for interpretation: “Do Blood Thinners Make You Tired?” surfacing while imagining the blood clotting process.

Do Blood Thinners Make You Tired or Not

Do Blood Thinners Make You Tired?

Have you seen that thick layer of blood stick over the periphery of your body part where the injury occurred? This is generally what they cite in the medical term “blood clot” in layman’s when blood forms a mass by sticking together blood platelets, protein, and cells.

To understand Fairly, Do Blood Thinners Make You Tired? Yes, it sometimes does. We’re comprehensively covering this topic here. Although, make sure for clinical advice, always choose the doctors and healthcare professionals. We’re here for educational and informational purposes to direct you to the qualitative approach for bare knowledge and understanding.

See More: Anticoagulation Safety

Understanding Fatigue: In the Shadow of Blood Thinners!

What is Fatigue?

What is Fatigue?

Fatigue is simply your body signaling the need for rejuvenation and rest. This feeling can be either from your mental or physical conditions and depends on factors such as your medical condition, medication side effects, drugs, sleep deprivation, and other lifestyle changes.

Will Blood Thinners Make You Tired?

If you’re feeling a bit sleepy, lacking motivation, or feeling worn out from your work, it might be your body’s way of asking for a well-deserved rest. However, there is no one cause to have fatigue. Does taking blood thinners make you tired? Yes, they do, per the reports conducted by various clinical surveys.

Do Blood Thinners Cause Fatigue?

Ensuring the correct dosage of blood thinners is important to maximize their benefits and minimize any potential side effects. Proper coordination of other medications, vitamins, and supplements is crucial to maintain the effectiveness of the primary medication and manage any potential side effects.

Blood Thinners Side Effects Fatigue

Fatigue is the most probable and potential side effect of blood thinners, although it does not affect everyone who takes the prescribed blood thinner medications. It treats the existing condition of blood clots or prevents them from happening.

Apart from blood thinners side effects fatigue, there are many other side effects, which are highlighted in the following block with regards to blood thinners and fatigue.

  • Anemia
  • Gastrointestinal Disturbances
  • Stress and Anxiety

Can Blood Thinners Make You Feel Tired?

Does Blood Thinner Make You Tired?

Blood thinners are the medication that professional doctors prescribe to prevent blood clotting. But, we must accept that no allopathic medicine leaves you without side effects. Here, we shall discuss some common side effects related to blood thinners.

Can blood thinners make you tired? Yes, they do. However, some symptoms are mild to severe, following side effects are most commonly found in patients.

  1. Bleeding is the number one cause behind blood thinners’ side effects fatigue is commonly found in almost every patient taking the blood thinner medication.
    • Bleeding can be internal and external; while bleeding is life-threatening, you cannot unequal the intensity and risk factors for internal and external bleeding.
    • What thins the thick blood – when it becomes too thinner crossing the appropriate medical bar, bleeding occurs, often due to excessive dosage or inappropriate and untimely application of the medication.
  2. Bruising Over the Skin, when those dark circles pop up over the region of injury or physical trauma, the Bruising takes form there, which can be visible.
    • When tiny blood vessels near the skin’s surface are affected, the blood may seep into the surrounding tissues. This can lead to a unique color change in the skin area due to the blood gathering under the skin.
    • However, the bruising condition is not so severe and may get healed on its own with time when the body reabsorbs the leaked blood.

According to the American Journal of Cardiology, around 2 to 3% of patients with blood thinners experience bleeding. Although, do blood thinners make you tired? Yes, they do. But, along with that, do blood thinners make you sleepy?

Some individuals may experience mild side effects such as headaches, nausea, diarrhea, hair changes, or skin sensitivity when using certain blood thinner medications. These effects are seen in a small fraction of users, between 1 to 6%. However, the severity cannot be defined by us since it will be permanently based on the specific health conditions and the patients and under the streamlined observation of professional expertise.

Generally, the application of thinner drugs for blood is not recommended during your pregnancy or while you’re in your breastfeeding period.

See More: Short-Term Disability Pregnancy Pre-Existing Condition

Does Eliquis Make You Tired?

A small percentage of individuals, between 2 to 6%, might feel a bit more tired than usual while taking Eliquis. This is a commonly heard side effect of this anticoagulant called “Apixaban,” an FDA Approved Generic Medicine under the brand name “Eliquis.” So, to ensure, does Eliquis make you tired? – You need not have to conduct an extensive thought line about your medicines and prefer to visit the clinic as the expertise would always make the difference in knowledge and preparations.

Does Eliquis Make you Tired?

Does Apixaban Make You Tired?

Apixaban, or “Eliquis,” is recommended by the “National Institute for Health and Care Excellence.” Its application has a range of medical prescriptions as follows.

Eliquis Side Effects Fatigue

While taking these medications, some individuals might experience a sense of fatigue. Often, this feeling is mild and subsides after a few days. In some instances, it might be more pronounced, but it’s important to remember that your healthcare provider is there to monitor your health and ensure your safety. We have gathered specific reports that indicate the eliquis side effects fatigue possibilities.

According to the reports, Apixaban or Eliquis is considered as most commonly prescribed medication, ranking 48th with more than 13 million prescriptions in the United States recognized by the World Health Organization’s model of essential medicine list.

Does Eiquis Cause Fatigue?

Can eliquis make you tired? Yes, they make you sleepy or tired, although the intensity may vary depending on the patient’s health condition.

As in the context of eliquis and fatigue, your healthcare provider is there to ensure your safety and well-being throughout the treatment process. The Food and Drug Administration in the US clears and approves Andexanet alfa as an antidote for the side effects of Eliquis or Apixaban.

Does Xarelto Make you Tired?

Remember, as it is the prescription a professional doctor gives in case of your blood clot problems, this medicine is called Rivaroxaban under the brand name “Xarelto.” It can also be prescribed for heart stroke risk and medical atrial fibrillation conditions.

While taking Xarelto, there might be instances where you could experience side effects that could contribute to feelings of fatigue. However, it’s important to remember that this is not a universal experience, and your healthcare provider is there to support you through this process.

Side Effects for the Xarelto

  • Bleeding
  • Bruising
  • Headache
  • Nausea
  • Dizziness
  • Muscle Pain
Does Xarelto Make you Tired?

Specific symptoms can serve as helpful indicators to monitor your body’s response to Xarelto. It’s important to remember that everyone does not experience these, and your healthcare provider is there to guide you through this process.

You must immediately contact your doctor for a clinical resolution if you find any following Xarelto side effects fatigue.

  • Difficulty in Breathing or Shortness of Breath
  • Blood in Urine or Stool
  • Discomfort in Chest or Chest Pain
  • Pain in legs or Swelling
  • Severe Headache or Vision Changes

According to the research, 1.4% of people get severe side effects from Xarelto. Bleeding is the most common side effect. This bleeding is considered both major and minor bleeding in clinical trials.

Major Bleeding Cases

0.54% to 4.9% per year

Minor Bleeding Cases

2.8% to 21.8% per year

While taking Xarelto, some individuals might experience more significant effects such as gastrointestinal (GI) bleeding and changes in liver function. However, these are not common for everyone and your healthcare provider will closely monitor your health to manage any potential risks.

  • 0.3% to 0.33% per year cases of GI Bleeding with the use of Xarelto, whereas Liver Function Abnormalities (LFA) are elevated by using Xarelto between the range of 0.6% to 16.3% per year.

It’s essential to be aware that stopping Xarelto prematurely could increase patients’ risk of thrombotic diseases.

However, it’s also crucial to remember that everyone’s experience with Xarelto can be unique. The effects of the medication can vary significantly from person to person, depending on their health conditions and other factors such as their response to the drug and their immune system.

Warfarin Side Effects Tiredness

Does Warfarin Make You Tired?

Warfarin is another anticoagulant medication that is used to prevent blood clotting conditions.

If you take warfarin and notice any Warfarin side effects, it’s essential to talk with your doctor. While fatigue is not a common side effect of warfarin, it can occur with other effects of blood thinners.

If you’re tired while taking warfarin, it could be due to other health conditions. This fatigue can sometimes be more pronounced, but it’s important to remember that this is not always the case.

warfarin side effects tiredness

Some people might experience mild discomforts like digestive issues, a sensation of coolness, skin sensitivity, or itching as potential side effects of warfarin. These are not necessarily common, but they can occur in some individuals.

While there can be more severe side effects associated with warfarin, these are not common, and your healthcare provider will monitor your health closely to manage any potential risks.

  • Intracranial Hemorrhage
  • gastrointestinal (GI) Bleed
  • Hematemesis
  • Intraocular Bleeding
  • Hemarthrosis

Jantoven and Coumadin are the two brand names under Warfarin. Although, these brands’ reputations are specific and vary based on region or location. Marevan, Lawarin, and Warfilone are other brands under this anticoagulant medicine.


In conclusion, do blood thinners make you tired or not and prepare you for your general awareness? The article highlights that approximately 1 in 5 patients experience fatigue after taking blood thinners.

While taking these medications, some individuals might notice minor changes such as occasional bruising, mild headaches, and digestive comfort. These effects are typically manageable and temporary. However, these are not experienced by everyone and can be managed effectively under the guidance of a healthcare professional.

Certain blood thinners, such as Eliquis and Xarelto, have the potential to contribute to feelings of fatigue. However, the intensity of this effect can vary greatly, depending on the individual’s overall health condition. It is crucial to consult healthcare professionals for personalized guidance and closely monitor side effects.

References: Eliquis

References: Xarelto

References: Warfarin


What are the most common side effects of blood thinners?

Bleeding and Bruising are considered the most common side effects of blood thinners. While headache, nausea, and dizziness are occasional side effects in individuals using blood thinners, these symptoms can often be managed under a healthcare professional’s guidance.

Do blood thinners make you cold and tired?

In many cases, can blood thinners cause fatigue, and doubts are repeated and cause fatigue or tiredness. Several factors, such as potential increased bleeding or bruising, anemia, or other underlying health conditions, could potentially lead to feelings of cold or fatigue

How long should you stay on blood thinners?

Based on the doctor’s recommendation and clinical prescription, the period of taking the blood thinners varies. Usually, it is between 3 to 4 months, and, in some cases, it may go beyond depending upon your health conditions.

Do anticoagulants make you tired?

Anticoagulants, also known as blood thinners, do, in some cases, cause fatigue as a direct side effect. However, as with any medication, individual responses can vary, and some people may experience fatigue while taking anticoagulants where else, some people may not.

Does thin blood make you tired?

While it’s possible, it’s not a universal experience. Whether blood thinners contribute to fatigue can depend on various factors, including the individual’s overall health and specific clinical factors. Your doctor will be able to monitor these factors to ensure your well-being.

Do blood thinners make you cold and tired?

Numerous factors, such as potential increased bleeding or bruising, anemia, or other underlying health conditions, could potentially lead to feelings of cold or fatigue. It’s always best to consult with your healthcare provider for personalized advice.

Brie Larson

Dr. Brie Larson, a seasoned physician, brings a wealth of medical knowledge and a strong commitment to patient education to her role at Medical Grants Help. A graduate from Stanford University School of Medicine, she has honed her expertise through years of patient care, delivering comprehensive healthcare services for individuals of all ages. Brie has a particular interest in expanding access to medical services through grants and funding initiatives. With her broad-based medical experience and a passion for patient advocacy, she navigates the complexities of medical grants, striving to make them more accessible for those in need. A steadfast believer in the transformative power of medical grants, Dr. Larson guides readers through the often overwhelming world of funding options, simplifying the process for patients and their families.

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